This Event is licensed under the Creative Commons BY-SA license. This license allows reusers to distribute, remix, adapt, and build upon the material in any medium or format, so long as attribution is given to the creator. The license allows for commercial use. If you remix, adapt, or build upon the material, you must license the modified material under identical terms.
Event: 2121
Key Event Title
decreased, Intellectual Quotient
Short name
Biological Context
Level of Biological Organization |
---|
Population |
Key Event Components
Key Event Overview
AOPs Including This Key Event
AOP Name | Role of event in AOP | Point of Contact | Author Status | OECD Status |
---|---|---|---|---|
Co-activation of IP3R and RyR to lower IQ | AdverseOutcome | Karine Audouze (send email) | Under development: Not open for comment. Do not cite | |
DNA methylation of FAM50B/PTCHD3 and IQ loss of children | AdverseOutcome | Huimin Ma (send email) | Under development: Not open for comment. Do not cite |
Taxonomic Applicability
Term | Scientific Term | Evidence | Link |
---|---|---|---|
humans | Homo sapiens | High | NCBI |
Life Stages
Life stage | Evidence |
---|---|
Juvenile | High |
3 to < 6 years | High |
6 to < 11 years | High |
During brain development | High |
Sex Applicability
Term | Evidence |
---|---|
Mixed | High |
Key Event Description
Intelligence Quotient (IQ) is a standardized measure of cognitive abilities, encompassing reasoning, problem-solving, and learning capacity.
A decrease in IQ reflects impairments in these domains and may indicate underlying neurodevelopmental disruptions. A decline in IQ refers to a statistically significant reduction in measured 'intelligence', as assessed by standardized IQ tests.
How It Is Measured or Detected
- WISC (Wechsler Intelligence Scale for Children)
Domain of Applicability
Regulatory Significance of the Adverse Outcome
The regulatory significance of IQ loss lies in its potential long-term impacts on societal outcomes, such as educational attainment, workforce productivity, and overall economic development. The loss of IQ points, especially in children, can lead to reduced cognitive abilities and lower lifetime earnings. Consequently, the implementation of regulations to limit exposure to harmful substances is crucial for protecting future generations and ensuring societal well-being.
References
Bouchard, M. F., Chevrier, J., Harley, K. G., Kogut, K., Vedar, M., Calderon, N., Trujillo, C., Johnson, C., Bradman, A., Barr, D. B., & Eskenazi, B. (2011). Prenatal exposure to organophosphate pesticides and IQ in 7-year-old children. Environmental health perspectives, 119(8), 1189–1195. https://doi.org/10.1289/ehp.1003185
Valuing the avoidance of IQ losses in children, 2023. OECD