API

Relationship: 1087

Title

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Decrease, E2 blood concentrations at hypothalamus leads to Increased, secretion of GnRH from hypothalamus

Upstream event

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Decrease, E2 blood concentrations at hypothalamus

Downstream event

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Increased, secretion of GnRH from hypothalamus

Key Event Relationship Overview

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AOPs Referencing Relationship

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AOP Name Directness Weight of Evidence Quantitative Understanding
Antiestrogen activity leading to ovarian adenomas and granular cell tumors in the mouse directly leads to Strong

Taxonomic Applicability

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Sex Applicability

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Life Stage Applicability

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How Does This Key Event Relationship Work

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Weight of Evidence

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Biological Plausibility

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Empirical Support for Linkage

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Uncertainties or Inconsistencies

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Quantitative Understanding of the Linkage

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Evidence Supporting Taxonomic Applicability

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References

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