API

Event: 1507

Key Event Title

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Activation of PPARγ

Short name

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Activation of PPARγ

Biological Context

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Level of Biological Organization
Molecular

Cell term

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Organ term

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Key Event Components

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Process Object Action

Key Event Overview


AOPs Including This Key Event

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Stressors

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Taxonomic Applicability

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Life Stages

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Sex Applicability

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Key Event Description

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How It Is Measured or Detected

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Domain of Applicability

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Evidence for Perturbation by Stressor



Tetrabromobisphenol A

TBBPA binds to PPARγ in vitro, with a Kd of 0.78 µM and in vivo in zebrafish, with a LOEL of 100 nM  (Fang et al., 2015; Riu et al., 2011; Riu et al., 2014). Mild activation has also been reported in vitro in several research papers and in ToxCast assays as well, with effective doses ranging from 0.3 to 10 µM (Riu et al., 2011; Riu et al., 2014; Suzuki et al., 2013; ToxCastTM Data; Watt and Schlezinger, 2015).


References

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