API

Event: 149

Key Event Title

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Increase, Inflammation

Short name

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Increase, Inflammation

Biological Context

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Level of Biological Organization
Cellular

Cell term

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Cell term
eukaryotic cell


Organ term

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Key Event Components

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Process Object Action
inflammatory response increased

Key Event Overview


AOPs Including This Key Event

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Stressors

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Taxonomic Applicability

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Life Stages

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Sex Applicability

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Key Event Description

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Damage of the epithelial layer lining the airways initiate inflammatory reactions.


How It Is Measured or Detected

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Activation of the innate immune response and the release of various inflammatory cytokines (Flake and Morgan, 2017).


Domain of Applicability

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References

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Flake, G. P., & Morgan, D. L. (2017). Pathology of diacetyl and 2,3-pentanedione airway lesions in a rat model of obliterative bronchiolitis. Toxicology, 388, 40–47. https://doi.org/10.1016/j.tox.2016.10.013

Palmer, S. M., Flake, G. P., Kelly, F. L., Zhang, H. L., Nugent, J. L., Kirby, P. J., … Morgan, D. L. (2011). Severe airway epithelial injury, aberrant repair and Bronchiolitis obliterans develops after diacetyl instillation in rats. PLoS ONE, 6(3). https://doi.org/10.1371/journal.pone.0017644