
This AOP is licensed under a Creative Commons Attribution 4.0 International License.
Aop: 115
Title
Epithelial cytotoxicity leading to forestomach tumors (in mouse and rat)
Short name
Graphical Representation
Contributors
- Charles Wood
Status
Author status | OECD status | OECD project | SAAOP status |
---|---|---|---|
Under Development: Contributions and Comments Welcome | 1.29 | Under Development |
This AOP was last modified on February 07, 2020 14:41
Revision dates for related pages
Page | Revision Date/Time |
---|---|
Increase, Cytotoxicity (epithelial cells) | September 16, 2017 10:16 |
Increase, Inflammation | January 30, 2019 10:26 |
Increase, Regenerative cell proliferation (forestomach epithelial cells) | September 16, 2017 10:16 |
Increase, Hyperplasia (forestomach epithelial cells) | September 16, 2017 10:16 |
Increase, Papillomas/carcinomas (squamous cells) | September 16, 2017 10:16 |
Increase, Cytotoxicity (epithelial cells) leads to Increase, Inflammation | December 03, 2016 16:38 |
Increase, Inflammation leads to Increase, Regenerative cell proliferation (forestomach epithelial cells) | December 03, 2016 16:38 |
Increase, Regenerative cell proliferation (forestomach epithelial cells) leads to Increase, Hyperplasia (forestomach epithelial cells) | December 03, 2016 16:38 |
Increase, Hyperplasia (forestomach epithelial cells) leads to Increase, Papillomas/carcinomas (squamous cells) | December 03, 2016 16:38 |
Abstract
This putative adverse outcome pathway (AOP) outlines potential key events leading to a tumor outcome in standard carcinogenicity models. This information is based largely on modes of action described previously in cited literature sources and is intended as a resource template for AOP development and data organization. Presentation in this Wiki does not indicate EPA acceptance of a particular pathway for a given reference agent, only that the information has been proposed in some manner. In addition, this putative AOP relates to the model species indicated and does not directly address issues of human relevance.
Background (optional)
Summary of the AOP
Events:
Molecular Initiating Events (MIE)
Key Events (KE)
Adverse Outcomes (AO)
Sequence | Type | Event ID | Title | Short name |
---|
1 | MIE | 780 | Increase, Cytotoxicity (epithelial cells) | Increase, Cytotoxicity (epithelial cells) |
2 | KE | 149 | Increase, Inflammation | Increase, Inflammation |
3 | KE | 781 | Increase, Regenerative cell proliferation (forestomach epithelial cells) | Increase, Regenerative cell proliferation (forestomach epithelial cells) |
4 | KE | 782 | Increase, Hyperplasia (forestomach epithelial cells) | Increase, Hyperplasia (forestomach epithelial cells) |
5 | AO | 779 | Increase, Papillomas/carcinomas (squamous cells) | Increase, Papillomas/carcinomas (squamous cells) |
Relationships Between Two Key Events (Including MIEs and AOs)
Title | Adjacency | Evidence | Quantitative Understanding |
---|
Network View
Stressors
Life Stage Applicability
Taxonomic Applicability
Sex Applicability
Sex | Evidence |
---|---|
Male | |
Female |
Overall Assessment of the AOP
Domain of Applicability
Essentiality of the Key Events
Evidence Assessment
Quantitative Understanding
Considerations for Potential Applications of the AOP (optional)
References
Proctor, D. M., Gatto, N. M., Hong, S. J., & Allamneni, K. P. (2007). Mode-of-action framework for evaluating the relevance of rodent forestomach tumors in cancer risk assessment. Toxicol Sci, 98(2), 313-326. doi: 10.1093/toxsci/kfm075