Key Event Title
|Level of Biological Organization|
Key Event Components
Key Event Overview
AOPs Including This Key Event
|AOP Name||Role of event in AOP|
|Inhibition fatty acid beta oxidation leading to nonalcoholic steatohepatisis (NASH)||KeyEvent|
|All life stages||High|
Key Event Description
Biological state: amount of fatty acid in the cytosol
Biological compartment: cytosol
General role in biology: fatty acids are a storage form for energy. Fatty acids are metabolized in hepatocytes into glucose.
How It Is Measured or Detected
Cytosolic fatty acid content can be measured in many ways. These include lipidomics approaches and histological staining.
Domain of Applicability
Fatty acids are well known energy storage molecules used in many vertebrates.