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Apoptosis leads to tumor growth
Key Event Relationship Overview
AOPs Referencing Relationship
Life Stage Applicability
Key Event Relationship Description
For KER 2, in vivo, Goode et al. showed that the knockout of the AhR in mice reduced tumor growth through an increase of cell apoptosis (Goode et al., 2013 Dec 15).
The relationship between decreased apoptosis and increase in tumor growth (KER 2) is not detailed here due to extensive evidence in the scientific literature (Hanahan and Weinberg, 2011 Mar 4).