API

Event: 804

Key Event Title

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Inhibition, HMG-CoA reductase

Short name

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Inhibition, HMG-CoA reductase

Biological Context

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Level of Biological Organization
Cellular

Cell term

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Organ term

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Key Event Components

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Process Object Action
hydroxymethylglutaryl-CoA reductase activity 3-hydroxy-3-methylglutaryl-coenzyme A reductase decreased

Key Event Overview


AOPs Including This Key Event

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AOP Name Role of event in AOP
HMGCR inhibition to male fertility MolecularInitiatingEvent

Stressors

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Taxonomic Applicability

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Life Stages

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Sex Applicability

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Key Event Description

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How It Is Measured or Detected

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The activity of HMG-CoA reductase inhibition may be measured by a commercially available kit which measures a decrease in absorbance at 340 nm, which represents the oxidation of NADPH by the catalytic subunit of HMGR in the presence of the substrate HMG-CoA. Sterol Regulatory element-binding factor 1 (SREBF) is the transcription factor controlling downstream regulation of HMG-CoA reductase. The ToxCast assay ATG_SREBF1_CIS_up is one method of measuring transcriptional control of HMG-CoA reductase.


Domain of Applicability

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Evidence for Perturbation by Stressor


Overview for Molecular Initiating Event

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References

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