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Increase, hypermethylation of the promotor region of GnRHR leads to Decease, expression of GnRHR
Key Event Relationship Overview
AOPs Referencing Relationship
|AOP Name||Adjacency||Weight of Evidence||Quantitative Understanding||Point of Contact||Author Status||OECD Status|
|Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR||adjacent||Moderate||Low||Jon Doering (send email)||Under development: Not open for comment. Do not cite|