Relationship: 1075
Title
Increased, secretion of local growth factors leads to Increased, IGF-1 (mouse)
Upstream event
Increased, secretion of local growth factorsDownstream event
Increased, IGF-1 (mouse)
Key Event Relationship Overview
AOPs Referencing Relationship
| AOP Name | Adjacency | Weight of Evidence | Quantitative Understanding |
|---|---|---|---|
| PPARgamma activation leading to sarcomas in rats, mice, and hamsters | adjacent | High |