API

Event: 1561

Key Event Title

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Neural tube defects

Short name

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Neural tube defects

Biological Context

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Level of Biological Organization
Tissue


Organ term

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Key Event Components

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Process Object Action

Key Event Overview


AOPs Including This Key Event

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AOP Name Role of event in AOP
HDAC inhibition leads to neural tube defects AdverseOutcome

Stressors

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Taxonomic Applicability

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Life Stages

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Sex Applicability

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Key Event Description

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Wrongly differentiated cells may not be able to perform the process of neural tube closure.


How It Is Measured or Detected

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In vitro assays that follow rosettes formation
In vivo animal models


Domain of Applicability

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Regulatory Significance of the Adverse Outcome

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References

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