API

Relationship: 61

Title

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Inhibition, Ca++ ATPase leads to Increase, Ca++ (intracellular)

Upstream event

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Inhibition, Ca++ ATPase

Downstream event

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Increase, Ca++ (intracellular)

Key Event Relationship Overview

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AOPs Referencing Relationship

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AOP Name Directness Weight of Evidence Quantitative Understanding
Calcium-mediated neuronal ROS production and energy imbalance directly leads to Strong

Taxonomic Applicability

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Sex Applicability

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Life Stage Applicability

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How Does This Key Event Relationship Work

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Weight of Evidence

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Biological Plausibility

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The purpose of the Ca++ ATPase is to pump Ca++ out of the cell [1],[2]. When the ATPase is inhibited, this will lead to an overall increase (relative) of intracellular calcium.

Empirical Support for Linkage

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Uncertainties or Inconsistencies

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Quantitative Understanding of the Linkage

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Evidence Supporting Taxonomic Applicability

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References

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  1. Jensen, TP; Buckby LE; Empson RM (2004). "Expression of plasma membrane Ca2+ ATPase family members and associated synaptic proteins in acute and cultured organotypic hippocampal slices from rat.". Brain Research. Developmental Brain Research. 152 (2): 129–136. doi:10.1016/j.devbrainres.2004.06.004. PMID 15351500.
  2. Feng, M.Y., Rao, R. 2013. New insights into store-independent Ca(2+) entry: secretory pathway calcium ATPase 2 in normal physiology and cancer.Int J Oral Sci 5(2): 71-4.