Inhibition, Ca++ ATPase leads to Increase, Ca++ (intracellular)
Upstream eventInhibition, Ca++ ATPase
Increase, Ca++ (intracellular)
Key Event Relationship Overview
AOPs Referencing Relationship
|AOP Name||Directness||Weight of Evidence||Quantitative Understanding|
|Calcium-mediated neuronal ROS production and energy imbalance||directly leads to||Strong|
Life Stage Applicability
How Does This Key Event Relationship Work
Weight of Evidence
Empirical Support for Linkage
Uncertainties or Inconsistencies
Quantitative Understanding of the Linkage
Evidence Supporting Taxonomic Applicability
- Jensen, TP; Buckby LE; Empson RM (2004). "Expression of plasma membrane Ca2+ ATPase family members and associated synaptic proteins in acute and cultured organotypic hippocampal slices from rat.". Brain Research. Developmental Brain Research. 152 (2): 129–136. doi:10.1016/j.devbrainres.2004.06.004. PMID 15351500.
- Feng, M.Y., Rao, R. 2013. New insights into store-independent Ca(2+) entry: secretory pathway calcium ATPase 2 in normal physiology and cancer.Int J Oral Sci 5(2): 71-4.