API

Event: 1615

Key Event Title

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Impaired inguinoscrotal testicular descent phase

Short name

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Impaired inguinoscrotal phase

Biological Context

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Level of Biological Organization
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Key Event Components

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Process Object Action

Key Event Overview


AOPs Including This Key Event

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AOP Name Role of event in AOP
Cyp17A1 inhibition leads to undescended testes in mammals KeyEvent

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Key Event Description

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Testis descent is based on a two-phase process: the transabdominal phase (INSL3-mediated) and the inguinoscrotal phase (Androgen-dependent). The transabdominal phase takes place in the first months of pregnancy, between 10 and 15 weeks. The inguinoscrotal phase occurs later in the fetus development, about 25-35 weeks of gestation. During this second phase, the testis is supposed to get into the scrotum. A defect in the inguinoscrotal phase results in a dysfunction in testis migration: the testis is stuck in the abdominal part of the body.1

Any impairment in testis migration, either through the transabdominal phase or the inguinoscrotal phase, will directly result in the absence of one or both testes from the scrotum.


How It Is Measured or Detected

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References

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1 Hutson J.M., Li R., Southwell B.R., Newgreen D., and Cousinery M. (2015) Regulation of testicular descent. Pediatric Surgery International, 31(4): 317-325 https://doi.org/10.1007/s00383-015-3673-4