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Event: 1615
Key Event Title
Impaired inguinoscrotal testicular descent phase
Short name
Biological Context
Level of Biological Organization |
---|
Organ |
Organ term
Organ term |
---|
gonad |
Key Event Components
Process | Object | Action |
---|---|---|
animal organ development | gonad | abnormal |
Key Event Overview
AOPs Including This Key Event
AOP Name | Role of event in AOP | Point of Contact | Author Status | OECD Status |
---|---|---|---|---|
Cyp17A1 inhibition leads to undescended testes in mammals | KeyEvent | Bérénice COLLET (send email) | Open for citation & comment | |
Decreased INSL3 leads to Increased, cryptorchidism | KeyEvent | John Frisch (send email) | Under development: Not open for comment. Do not cite |
Taxonomic Applicability
Term | Scientific Term | Evidence | Link |
---|---|---|---|
mammals | mammals | Moderate | NCBI |
Life Stages
Life stage | Evidence |
---|---|
During development and at adulthood | Moderate |
Sex Applicability
Term | Evidence |
---|---|
Male | High |
Key Event Description
Testis descent is based on a two-phase process: the transabdominal phase (INSL3-mediated) and the inguinoscrotal phase (Androgen-dependent). The transabdominal phase takes place in the first months of pregnancy, between 10 and 15 weeks. In humans, the inguinoscrotal phase occurs later in the fetus development, about 25-35 weeks of gestation. During this second phase, the testis is supposed to get into the scrotum. A defect in the inguinoscrotal phase results in a dysfunction in testis migration: the testis is stuck in the abdominal part of the body.1
Any impairment in testis migration, either through the transabdominal phase or the inguinoscrotal phase, will directly result in the absence of one or both testes from the scrotum.
How It Is Measured or Detected
Issues during development can be detected by histological exam, with physical manifestation of abnormal development visible in mature individuals.
Domain of Applicability
Life Stage: Problems first can be observed during development, with adverse outcome manifesting in mature individuals.
Sex: Applies to males.
Taxonomic: Appears to be present broadly in mammals, with most representative studies in mammals (humans, lab mice, lab rats). Restricted to organisms with descended testes.
References
1 Hutson J.M., Li R., Southwell B.R., Newgreen D., and Cousinery M. (2015) Regulation of testicular descent. Pediatric Surgery International, 31(4): 317-325 https://doi.org/10.1007/s00383-015-3673-4
NOTE: Italics symbolize edits from John Frisch