API

Event: 1559

Key Event Title

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Facial cartilage structures are reduced in size and morphologically distorted

Short name

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Smaller and morphologically distorted facial cartilage structures

Biological Context

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Level of Biological Organization
Tissue


Organ term

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Key Event Components

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Process Object Action

Key Event Overview


AOPs Including This Key Event

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AOP Name Role of event in AOP
HDAC inhibition leads to impeded craniofacial development AdverseOutcome

Stressors

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Taxonomic Applicability

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Life Stages

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Sex Applicability

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Key Event Description

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In order for cartilage structures to form, chondrocytes need to secrete large amounts of collagen. One outcome of the disturbances of NCC migration and differentiation is the distortion and reduced size of facial cartilage structures.


How It Is Measured or Detected

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The appearance of facial cartilage structures is readily visible in ventral views of zebrafish embryos at 5 days post fertilization. Such structures as the ceratohyal, Meckel’s cartilage, and the palatoquadrate are visible using fluorescent collagen reporter lines. Measurements of the angle formed by the ceratohyal provide a quantitative readout.


Domain of Applicability

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Regulatory Significance of the Adverse Outcome

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References

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