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Increase, Plasma vitellogenin concentrations leads to Increase, Renal pathology due to VTG deposition
Key Event Relationship Overview
AOPs Referencing Relationship
|AOP Name||Adjacency||Weight of Evidence||Quantitative Understanding||Point of Contact||Author Status||OECD Status|
|Estrogen receptor agonism leading to reproductive dysfunction||adjacent||High||Tom Hutchinson (send email)||Under Development: Contributions and Comments Welcome|
Life Stage Applicability
Key Event Relationship Description
Evidence Supporting this KER
High level of biological plausibility in fish.
Uncertainties and Inconsistencies
None that the author of this entry is aware of.
Known modulating factors
Known Feedforward/Feedback loops influencing this KER
Domain of Applicability
Publish studies specifically relate to fish, although it is plausible that the same response may occur in the aquatic life-stages of amphibians.
Herman, R.L., Kincaid, H.L. (1988) Pathological effects of orally administered 17beta-estradiol to rainbow trout. Aquaculture 72:165–172
Länge, R., Hutchinson, T.H., Croudace, C.P., Siegmund, F., Schweinfurth, H., Hampe, P., Panter, G.H., Sumpter, J.P. (2001) Effects of the synthetic estrogen 17 alpha-ethinylestradiol on the life-cycle of the fathead minnow (Pimephales promelas). Environ Toxicol Chem 20:1216-1227