API

Relationship: 254

Title

?

Increase, Plasma vitellogenin concentrations leads to Increase, Renal pathology due to VTG deposition

Upstream event

?

Increase, Plasma vitellogenin concentrations

Downstream event

?


Increase, Renal pathology due to VTG deposition

Key Event Relationship Overview

?


AOPs Referencing Relationship

?

AOP Name Directness Weight of Evidence Quantitative Understanding
Estrogen receptor agonism leading to reproductive dysfunction directly leads to Strong

Taxonomic Applicability

?


Sex Applicability

?


Life Stage Applicability

?


How Does This Key Event Relationship Work

?


Weight of Evidence

?


Biological Plausibility

?

High level of biological plausibility in fish.

Empirical Support for Linkage

?

Laboratory in vivo aquatic exposures of fish (fathead minnow) to 17alpha-ethinylestradiol led to renal pathology within 16 weeks, concomitant with macroscopic evidence of osmoregulatory dysfunction and morbidity (Laenge et al., 2001).

Uncertainties or Inconsistencies

?

None that the author of this entry is aware of.

Quantitative Understanding of the Linkage

?


Published studies include 17beta-estradiol and 17alpha-ethinylestradiol as known modulators of this relationship in fish. Model fish species (eg fathead minnow) have been used to study this biological effect and while there are no quantitative extrapolation models published to date, empirical data suggests renal pathology occurs in juvenile or male fish when plasma VTG levels are >1000-fold above baseline for a period of several weeks.

Evidence Supporting Taxonomic Applicability

?


Publish studies specifically relate to fish, although it is plausible that the same response may occur in the aquatic life-stages of amphibians.

References

?


Herman, R.L., Kincaid, H.L. (1988) Pathological effects of orally administered 17beta-estradiol to rainbow trout. Aquaculture 72:165–172

Länge, R., Hutchinson, T.H., Croudace, C.P., Siegmund, F., Schweinfurth, H., Hampe, P., Panter, G.H., Sumpter, J.P. (2001) Effects of the synthetic estrogen 17 alpha-ethinylestradiol on the life-cycle of the fathead minnow (Pimephales promelas). Environ Toxicol Chem 20:1216-1227