API

Event: 1490

Key Event Title

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Inhibition, Fatty Acid Beta Oxidation

Short name

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Inhibition of fatty acid beta oxidation

Biological Context

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Level of Biological Organization
Molecular

Cell term

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Organ term

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Key Event Components

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Process Object Action

Key Event Overview


AOPs Including This Key Event

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AOP Name Role of event in AOP
Inhibition fatty acid beta oxidation leading to nonalcoholic steatohepatisis (NASH) MolecularInitiatingEvent

Stressors

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Taxonomic Applicability

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Life Stages

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Sex Applicability

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Key Event Description

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Biological state being measured: fatty acid beta oxidation

Biological compartment: mitochondria or peroxisome

General role in biology: Fatty acid beta oxidation (FABO) is the process by which fatty acids are metabolized into glucose for energy utilization. 


How It Is Measured or Detected

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Fatty acid beta oxidation (FABO) can be measured by:

1) Activity of the enzymes that perform FABO

2) Flourescence assays measuring extracellular oxygen consumption

3) Radiolabel assays using labeled palmitate


Domain of Applicability

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This is a well-known metabolic pathway.


Evidence for Perturbation by Stressor


Overview for Molecular Initiating Event

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References

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