API

Event: 770

Key Event Title

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Increase, Cytotoxicity (club cells)

Short name

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Increase, Cytotoxicity (club cells)

Key Event Component

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Process Object Action
cell death Clara cell increased

Key Event Overview


AOPs Including This Key Event

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AOP Name Role of event in AOP
Cytotoxicity leading to bronchioloalveolar adenomas and carcinomas (in mouse) MolecularInitiatingEvent

Stressors

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Level of Biological Organization

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Biological Organization
Cellular

Cell term

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Cell term
Clara cell


Organ term

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Taxonomic Applicability

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Life Stages

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Sex Applicability

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How This Key Event Works

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This key event can be associated with Cyp2f2 bioactivation.


How It Is Measured or Detected

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Evidence Supporting Taxonomic Applicability

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Evidence for Perturbation by Stressor


Overview for Molecular Initiating Event

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References

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