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Aop: 109

AOP Title

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Cytotoxicity leading to bronchioloalveolar adenomas and carcinomas (in mouse)

Short name:

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Cytotoxicity- bronchiolar adenoma/carcinoma

Graphical Representation

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Click to download graphical representation template

Authors

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Cancer AOP group. National Health and Environmental Effects Research Laboratory, Office of Research and Development, Integrated Systems Toxicology Division, US Environmental Protection Agency, Research Triangle Park, NC. Corresponding author for wiki entry (wood.charles@epa.gov)

Point of Contact

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Charles Wood   (email point of contact)

Contributors

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  • Charles Wood

Status

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Author status OECD status OECD project SAAOP status
Under development: Not open for comment. Do not cite 1.29 Under Development


This AOP was last modified on January 27, 2018 15:34

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Revision dates for related pages

Page Revision Date/Time
Increase, Necrosis (terminal bronchiolar cells) September 16, 2017 10:16
Increase, Regenerative cell proliferation (terminal bronchiolar epithelial cells) December 03, 2016 16:37
Increase, Hyperplasia (terminal bronchiolar cells) September 16, 2017 10:16
Increase, Adenomas/carcinomas (bronchioloalveolar) September 16, 2017 10:16
Increase, Cytotoxicity (club cells) September 16, 2017 10:16
Increase, Necrosis (terminal bronchiolar cells) leads to Increase, Regenerative cell proliferation (terminal bronchiolar epithelial cells) December 03, 2016 16:37
Increase, Regenerative cell proliferation (terminal bronchiolar epithelial cells) leads to Increase, Hyperplasia (terminal bronchiolar cells) December 03, 2016 16:37
Increase, Hyperplasia (terminal bronchiolar cells) leads to Increase, Adenomas/carcinomas (bronchioloalveolar) December 03, 2016 16:37
Increase, Cytotoxicity (club cells) leads to Increase, Necrosis (terminal bronchiolar cells) December 03, 2016 16:38

Abstract

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This putative adverse outcome pathway (AOP) outlines potential key events leading to a tumor outcome in standard carcinogenicity models. This information is based largely on modes of action described previously in cited literature sources and is intended as a resource template for AOP development and data organization. Presentation in this Wiki does not indicate EPA acceptance of a particular pathway for a given reference agent, only that the information has been proposed in some manner. In addition, this putative AOP relates to the model species indicated and does not directly address issues of human relevance.


Background (optional)

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Summary of the AOP

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Events: Molecular Initiating Events (MIE)

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Key Events (KE)

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Adverse Outcomes (AO)

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Sequence Type Event ID Title Short name
1 MIE 770 Increase, Cytotoxicity (club cells) Increase, Cytotoxicity (club cells)
2 KE 733 Increase, Necrosis (terminal bronchiolar cells) Increase, Necrosis (terminal bronchiolar cells)
3 KE 734 Increase, Regenerative cell proliferation (terminal bronchiolar epithelial cells) Increase, Regenerative cell proliferation (terminal bronchiolar epithelial cells)
4 KE 735 Increase, Hyperplasia (terminal bronchiolar cells) Increase, Hyperplasia (terminal bronchiolar cells)
5 AO 736 Increase, Adenomas/carcinomas (bronchioloalveolar) Increase, Adenomas/carcinomas (bronchioloalveolar)

Relationships Between Two Key Events
(Including MIEs and AOs)

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Title Adjacency Evidence Quantitative Understanding
Increase, Necrosis (terminal bronchiolar cells) leads to Increase, Regenerative cell proliferation (terminal bronchiolar epithelial cells) adjacent
Increase, Regenerative cell proliferation (terminal bronchiolar epithelial cells) leads to Increase, Hyperplasia (terminal bronchiolar cells) adjacent
Increase, Hyperplasia (terminal bronchiolar cells) leads to Increase, Adenomas/carcinomas (bronchioloalveolar) adjacent
Increase, Cytotoxicity (club cells) leads to Increase, Necrosis (terminal bronchiolar cells) adjacent

Network View

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Stressors

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Life Stage Applicability

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Taxonomic Applicability

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Term Scientific Term Evidence Link
Mus musculus Mus musculus NCBI

Sex Applicability

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Sex Evidence
Male
Female

Overall Assessment of the AOP

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Domain of Applicability

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Essentiality of the Key Events

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Evidence Assessment

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Quantitative Understanding

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Considerations for Potential Applications of the AOP (optional)

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References

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