API

Relationship: 1883

Title

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Increase, DNMT inhibition leads to Increase, DNA hypomethylation

Upstream event

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Increase, DNMT inhibition

Downstream event

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Increase, DNA hypomethylation

Key Event Relationship Overview

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AOPs Referencing Relationship

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AOP Name Adjacency Weight of Evidence Quantitative Understanding
Mitochondrial ATP synthase inhibition leading to growth arrest (1) adjacent High
Mitochondrial ATP synthase inhibition leading to growth arrest (2) adjacent High

Taxonomic Applicability

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Sex Applicability

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Life Stage Applicability

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Key Event Relationship Description

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Evidence Supporting this KER

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Biological Plausibility

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Empirical Evidence

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Uncertainties and Inconsistencies

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Quantitative Understanding of the Linkage

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Response-response Relationship

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Time-scale

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Known modulating factors

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Known Feedforward/Feedback loops influencing this KER

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Domain of Applicability

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References

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