API

Relationship: 432

Title

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Increased, Atrioventricular block and bradycardia leads to Increased, Mortality

Upstream event

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Increased, Atrioventricular block and bradycardia

Downstream event

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Increased, Mortality

Key Event Relationship Overview

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AOPs Referencing Relationship

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AOP Name Adjacency Weight of Evidence Quantitative Understanding
Acetylcholinesterase inhibition leading to acute mortality adjacent Low Low

Taxonomic Applicability

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Sex Applicability

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Life Stage Applicability

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Key Event Relationship Description

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Severe arrhythmias or a heart rate insufficient to supply oxygen to the rest of the body can result in mortality.

Evidence Supporting this KER

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Biological Plausibility

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Empirical Evidence

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Not assembled.

Uncertainties and Inconsistencies

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Quantitative Understanding of the Linkage

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Not evaluated.

Response-response Relationship

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Time-scale

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Known modulating factors

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Known Feedforward/Feedback loops influencing this KER

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Domain of Applicability

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References

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