Key Event Title
|Level of Biological Organization|
Key Event Components
Key Event Overview
AOPs Including This Key Event
|AOP Name||Role of event in AOP|
|PPARγ inactivation leading to lung fibrosis||MolecularInitiatingEvent|
|TLR4 activation, PPAR gamma activation and Pulmonary fibrosis||MolecularInitiatingEvent|
Key Event Description
Following pulmonary exposure, the stressor interacts with cellular membranes of alveolar macrophages, other inflammatory cells, epithelial cells and proteins (lung surfactants) in the lung space.
The stressor acts as an antagonist of PPARγ of epithelial and inflammatory cells in the lung.
How It Is Measured or Detected
Domain of Applicability
Evidence for Perturbation by Stressor
Overview for Molecular Initiating Event