API

Event: 1270

Key Event Title

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Inactivation of PPARγ

Short name

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Inactivation of PPARγ

Biological Context

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Level of Biological Organization
Molecular

Cell term

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Organ term

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Key Event Components

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Process Object Action

Key Event Overview


AOPs Including This Key Event

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AOP Name Role of event in AOP
PPARγ inactivation leading to lung fibrosis MolecularInitiatingEvent

Stressors

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Taxonomic Applicability

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Life Stages

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Sex Applicability

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Key Event Description

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Following pulmonary exposure, the stressor interacts with cellular membranes of alveolar macrophages, other inflammatory cells, epithelial cells and proteins (lung surfactants) in the lung space.

The stressor acts as an antagonist of PPARγ of epithelial and inflammatory cells in the lung.


How It Is Measured or Detected

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Domain of Applicability

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Evidence for Perturbation by Stressor


Overview for Molecular Initiating Event

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References

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