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Aop: 347

AOP Title

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Toll-like receptor 4 activation and peroxisome proliferator-activated receptor gamma activation leading to pulmonary fibrosis

Short name:

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TLR4 activation, PPAR gamma activation and Pulmonary fibrosis

Graphical Representation

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Click to download graphical representation template

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Authors

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Seokjoo Yoon, Korea Institute of Toxicology, South Korea

Woo-Keun Kim, Korea Institute of Toxicology, South Korea

Mikyung Song, Korea Institute of Toxicology, South Korea

Kyuhong Lee, Korea Institute of Toxicology, South Korea

Sangwoo Lee, Korea Institute of Toxicology, South Korea

Point of Contact

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Seokjoo Yoon   (email point of contact)

Contributors

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  • Seokjoo Yoon

Status

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Author status OECD status OECD project SAAOP status
Under development: Not open for comment. Do not cite


This AOP was last modified on July 09, 2020 03:34

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Revision dates for related pages

Page Revision Date/Time
Toll-like receptor 4 activation July 09, 2020 02:59
Inactivation of PPARγ December 26, 2017 02:12
Activation, JNK September 16, 2017 10:17
Activator protein 1 activation July 09, 2020 03:07
Pin-1 activation July 09, 2020 03:10
Latent Transforming growth Factor beta expression July 09, 2020 03:14
Activation, TGF-beta pathway September 16, 2017 10:17
Induction, Epithelial Mesenchymal Transition January 30, 2019 10:27
Pulmonary fibrosis November 01, 2019 11:51
TLR4 activation leads to Activation, JNK July 09, 2020 03:19
Activation, JNK leads to AP-1 activation July 09, 2020 03:20
Activation, JNK leads to Pin-1 activation July 09, 2020 03:20
Pin-1 activation leads to TGFbeta expression July 09, 2020 03:20
TGFbeta expression leads to Activation, TGF-beta pathway July 09, 2020 03:21
Activation, TGF-beta pathway leads to EMT July 09, 2020 03:21
EMT leads to Pulmonary fibrosis July 09, 2020 03:22
Inactivation of PPARγ leads to Activation, TGF-beta pathway July 09, 2020 03:23
AP-1 activation leads to TGFbeta expression July 09, 2020 03:24

Abstract

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Background (optional)

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Summary of the AOP

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Events: Molecular Initiating Events (MIE)

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Key Events (KE)

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Adverse Outcomes (AO)

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Sequence Type Event ID Title Short name
MIE 1792 Toll-like receptor 4 activation TLR4 activation
MIE 1270 Inactivation of PPARγ Inactivation of PPARγ
KE 1292 Activation, JNK Activation, JNK
KE 1793 Activator protein 1 activation AP-1 activation
KE 1794 Pin-1 activation Pin-1 activation
KE 1795 Latent Transforming growth Factor beta expression TGFbeta expression
KE 1283 Activation, TGF-beta pathway Activation, TGF-beta pathway
KE 1457 Induction, Epithelial Mesenchymal Transition EMT
AO 1458 Pulmonary fibrosis Pulmonary fibrosis

Relationships Between Two Key Events
(Including MIEs and AOs)

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Title Adjacency Evidence Quantitative Understanding
TLR4 activation leads to Activation, JNK adjacent Not Specified Not Specified
Activation, JNK leads to AP-1 activation adjacent Not Specified Not Specified
Activation, JNK leads to Pin-1 activation adjacent Not Specified Not Specified
Pin-1 activation leads to TGFbeta expression adjacent Not Specified Not Specified
TGFbeta expression leads to Activation, TGF-beta pathway adjacent Not Specified Not Specified
Activation, TGF-beta pathway leads to EMT adjacent Not Specified Not Specified
EMT leads to Pulmonary fibrosis adjacent Not Specified Not Specified
Inactivation of PPARγ leads to Activation, TGF-beta pathway adjacent Not Specified Not Specified
AP-1 activation leads to TGFbeta expression adjacent Not Specified Not Specified

Network View

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Stressors

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Life Stage Applicability

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Taxonomic Applicability

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Sex Applicability

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Sex Evidence
Unspecific Not Specified

Overall Assessment of the AOP

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Domain of Applicability

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Essentiality of the Key Events

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Evidence Assessment

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Quantitative Understanding

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Considerations for Potential Applications of the AOP (optional)

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References

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