API

Event: 115

Key Event Title

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Increase, FA Influx

Short name

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Increase, FA Influx

Key Event Component

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Process Object Action
positive regulation of fatty acid transport fatty acid increased

Key Event Overview


AOPs Including This Key Event

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AOP Name Role of event in AOP
LXR activation leading to hepatic steatosis KeyEvent

Stressors

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Level of Biological Organization

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Biological Organization
Cellular

Cell term

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Cell term
hepatocyte


Organ term

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Taxonomic Applicability

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Life Stages

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Sex Applicability

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How This Key Event Works

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Fat influx to the liver is usually increased under condition like obesity. Free fatty acids (FFA) increase in blood leads to an increase of FFA uptake in the liver. Especially the long chain fatty acids (LCFAs) are translocated across the plasma membrane, reassembled to triglycerides and stored in lipid droplets causing hepatic steatosis [1].

As mentioned above CD36 has consistently been shown to be expressed at the plasma membrane and to enhance LCFA uptake upon over-expression [2], [3].


How It Is Measured or Detected

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Evidence Supporting Taxonomic Applicability

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References

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  1. Amacher 2011
  2. Baranowski 2008
  3. Su & Abumrad 2009