API

Relationship: 212

Title

?

Decreased, Nitric Oxide leads to Decreased, Long-term potentiation (LTP)

Upstream event

?

Decreased, Nitric Oxide

Downstream event

?


Decreased, Long-term potentiation (LTP)

Key Event Relationship Overview

?


AOPs Referencing Relationship

?

AOP Name Directness Weight of Evidence Quantitative Understanding
Calcium-mediated neuronal ROS production and energy imbalance directly leads to Moderate

Taxonomic Applicability

?


Sex Applicability

?


Life Stage Applicability

?


How Does This Key Event Relationship Work

?


Weight of Evidence

?


Biological Plausibility

?

Empirical Support for Linkage

?

  • Nitric oxide (NO) is important for Long-term potentiation (LTP). NO synthesase inhibitor administration prevents LTP [1].

Uncertainties or Inconsistencies

?

Quantitative Understanding of the Linkage

?


Evidence Supporting Taxonomic Applicability

?


References

?


  1. Bon, C.L.M., Garthwaite, J. 2003. J Neurosci 23(5): 1941-48.