Decreased, Nitric Oxide leads to Decreased, Long-term potentiation (LTP)
Upstream eventDecreased, Nitric Oxide
Decreased, Long-term potentiation (LTP)
Key Event Relationship Overview
AOPs Referencing Relationship
|AOP Name||Directness||Weight of Evidence||Quantitative Understanding|
|Calcium-mediated neuronal ROS production and energy imbalance||directly leads to||Moderate|
Life Stage Applicability
How Does This Key Event Relationship Work
Weight of Evidence
Empirical Support for Linkage
- Nitric oxide (NO) is important for Long-term potentiation (LTP). NO synthesase inhibitor administration prevents LTP .
Uncertainties or Inconsistencies
Quantitative Understanding of the Linkage
Evidence Supporting Taxonomic Applicability
- Bon, C.L.M., Garthwaite, J. 2003. J Neurosci 23(5): 1941-48.