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Activation/Proliferation, T-cells leads to sensitisation, skin
Key Event Relationship Overview
AOPs Referencing Relationship
|AOP Name||Adjacency||Weight of Evidence||Quantitative Understanding||Point of Contact||Author Status||OECD Status|
|Covalent Protein binding leading to Skin Sensitisation||adjacent||High||Sharon Munn (send email)||Open for citation & comment||WPHA/WNT Endorsed|
Life Stage Applicability
Key Event Relationship Description
After recognition of a non-self peptide (i.e. foreign) presented by dendritic cells, T-cells are activated and form memory T-cell, which proliferate. If reactivated upon hapten presentation by skin dendritic cells, these memory T-cells will induce allergic contact dermatitis).
This KER description is based only on the OECD document 2012 and needs updating.
Evidence Supporting this KER
It is well known, recognised and experimentally proved that skin sensitisation is a T-cell mediated immune response.
Uncertainties and Inconsistencies
Known modulating factors
Known Feedforward/Feedback loops influencing this KER
Domain of Applicability
- Vocanson M, Hennino A, Rozieres A, Poyet G, Nicolas JF. 2009. Effector and regulatory mechanisms in allergic contact dermatitis. Allergy 64: 1699-1714.
- Engeman T, Gorbachev AV, Kish DD, Fairchild RL. 2004. The intensity of neutrophil infiltration controls the number of antigen-primed CD8 T cells recruited into cutaneous antigen challenge sites. J. Leukocyte Biol. 76:941-949.