API

Event: 1570

Key Event Title

?

Blocking of IL-1R

Short name

?

Blocking of IL-1R

Biological Context

?

Level of Biological Organization
Molecular

Cell term

?


Organ term

?


Key Event Components

?

Process Object Action

Key Event Overview


AOPs Including This Key Event

?

AOP Name Role of event in AOP
IL-1 inhibition MolecularInitiatingEvent

Stressors

?


Taxonomic Applicability

?


Life Stages

?


Sex Applicability

?


Key Event Description

?


 IL-la and IL-1b bind with high affinity to cell-surface receptors found on numerous cell types (1, 2).


How It Is Measured or Detected

?



Domain of Applicability

?



Evidence for Perturbation by Stressor


Overview for Molecular Initiating Event

?



References

?


  • Dripps, D.J., Brandhuber, B.J., Thompson, R.C., Eisenberg, S.P. (1991). J Biol Chem 266 (16): 10331-6.