Relationship: 1274
Title
Opening of calcium channel, Calcium influx leads to Excitation, Trigeminal nerve excitation
Upstream event
Opening of calcium channel, Calcium influxDownstream event
Excitation, Trigeminal nerve excitation
Key Event Relationship Overview
AOPs Referencing Relationship
| AOP Name | Adjacency | Weight of Evidence | Quantitative Understanding |
|---|---|---|---|
| Volatile Organic Chemicals Activate TRPA1 Receptor to Induce Sensory Pulmonary Irritation | adjacent | High | High |
Taxonomic Applicability
Sex Applicability
Life Stage Applicability
Key Event Relationship Description
Sufficient depolarization of the neuronal membrane from increased calcium may trigger voltage-gated sodium channels leading to propagation of action potential(s).
Evidence Supporting this KER
Empirical Evidence
The basic biology of neuronal action potentials is outside the scope of this review, but is widely available in textbooks and online educational resources.