Upstream eventOpening of calcium channel, Calcium influx
Excitation, Trigeminal nerve excitation
Key Event Relationship Overview
AOPs Referencing Relationship
|AOP Name||Adjacency||Weight of Evidence||Quantitative Understanding|
|Volatile Organic Chemicals Activate TRPA1 Receptor to Induce Sensory Pulmonary Irritation||adjacent||High||High|
Life Stage Applicability
Key Event Relationship Description
Sufficient depolarization of the neuronal membrane from increased calcium may trigger voltage-gated sodium channels leading to propagation of action potential(s).
Evidence Supporting this KER
The basic biology of neuronal action potentials is outside the scope of this review, but is widely available in textbooks and online educational resources.