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Activation, estrogen receptor alpha leads to Impaired, Reproduction
Key Event Relationship Overview
AOPs Referencing Relationship
|AOP Name||Adjacency||Weight of Evidence||Quantitative Understanding||Point of Contact||Author Status||OECD Status|
|Estrogen Receptor Alpha Agonism leads to Impaired Reproduction||non-adjacent||High||Moderate||John Hoang (send email)||Under development: Not open for comment. Do not cite|
Life Stage Applicability
Key Event Relationship Description
Evidence Collection Strategy
The majority of papers used in evidence supporting the non-direct key event relationship between activation of estrogen receptor alpha and impaired reproduction were found through the Ecotox knowledgebase search. In this search, papers were found using 4 estrogen chemicals(17β-estradiol(E2), 17α-Ethinylestradiol(EE2), estrone(E1), and diethylstilbestrol) and 4 model fish species(Danio rerio, Oncorhynchus mykiss, Pimephales promelas, Oryzias latipes). This yielded 326 references which were then subsequently filtered in Swift Review using the chemicals and fish species as filters. An initial subset of 47 papers was used towards compiling the weight of evidence for this relationship with Pimephales promelas as the primary fish filter. Additional sources used in the weight of evidence were provided through expert knowledge.