API

Relationship: 2201

Title

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Antagonism, Androgen receptor leads to Altered, Transcription of genes by AR

Upstream event

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Antagonism, Androgen receptor

Downstream event

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Altered, Transcription of genes by AR

Key Event Relationship Overview

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AOPs Referencing Relationship

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AOP Name Adjacency Weight of Evidence Quantitative Understanding
Androgen receptor (AR) antagonism leading to decreased fertility in females adjacent High Moderate

Taxonomic Applicability

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Term Scientific Term Evidence Link
rat Rattus norvegicus High NCBI
human Homo sapiens High NCBI
mouse Mus musculus High NCBI
zebrafish Danio rerio High NCBI

Sex Applicability

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Sex Evidence
Male High
Female High

Life Stage Applicability

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Term Evidence
All life stages High

Key Event Relationship Description

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The AR is a nuclear hormone receptor that functions primarily as a transcription factor. After binding of a ligand (androgens: DHT, testosterone) to the AR, the androgen-AR complex translocate to the nucleus and bind to specific hormone response elements on the DNA duplex to regulate gene transcription. The AR is expressed in various cells and tissues throughout the body in a spatiotemporal manner, with levels and activation changed in response to androgen signaling (Chang et al, 1995; Davey & Grossmann, 2016; Roy et al, 1999).

Evidence Supporting this KER

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Biological Plausibility

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Empirical Evidence

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Uncertainties and Inconsistencies

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Quantitative Understanding of the Linkage

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Response-response Relationship

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Time-scale

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Known modulating factors

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Known Feedforward/Feedback loops influencing this KER

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Domain of Applicability

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References

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