API

Relationship: 380

Title

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Response, Keratinocytes leads to Activation/Proliferation, T-cells

Upstream event

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Response, Keratinocytes

Downstream event

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Activation/Proliferation, T-cells

Key Event Relationship Overview

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AOPs Referencing Relationship

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Taxonomic Applicability

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Sex Applicability

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Life Stage Applicability

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Key Event Relationship Description

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Despite the graphical representation Figure 3 "Flow diagram of the pathways associated with skin sensitisation", suggests this relationship, no information could be found in this document [1] supporting this link.

Evidence Supporting this KER

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Biological Plausibility

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Empirical Evidence

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Uncertainties and Inconsistencies

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Quantitative Understanding of the Linkage

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Response-response Relationship

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Time-scale

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Known modulating factors

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Known Feedforward/Feedback loops influencing this KER

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Domain of Applicability

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References

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  1. OECD (2012a) The Adverse Outcome Pathway for Skin Sensitisation Initiated by Covalent Binding to Proteins. Part 1: Scientific Evidence. Series on Testing and Assessment No. 168. Available at: http://www.oecd.org/officialdocuments/publicdisplaydocumentpdf/?cote=ENV/JM/MONO(2012)10/PART1&docLanguage=En