API

Relationship: 60

Title

?

Increase, Ca++ (intracellular) leads to Disruption, Mitochondrial electron transport chain

Upstream event

?

Increase, Ca++ (intracellular)

Downstream event

?


Disruption, Mitochondrial electron transport chain

Key Event Relationship Overview

?


AOPs Referencing Relationship

?

AOP Name Directness Weight of Evidence Quantitative Understanding
Calcium-mediated neuronal ROS production and energy imbalance directly leads to Moderate

Taxonomic Applicability

?


Sex Applicability

?


Life Stage Applicability

?


How Does This Key Event Relationship Work

?


Weight of Evidence

?


Biological Plausibility

?

Empirical Support for Linkage

?

  • Mitochondrial electron transport chain disruption follows intracellular Ca++ dysregulation [1]

Uncertainties or Inconsistencies

?

Quantitative Understanding of the Linkage

?


Evidence Supporting Taxonomic Applicability

?


References

?


  1. Lebrecht D1, Kirschner J, Geist A, Haberstroh J, Walker UA. 2010. Cardiovasc Pathol 19(5): e167-74.