API

Relationship: 60

Title

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Increase, Ca++ (intracellular) leads to Disruption, Mitochondrial electron transport chain

Upstream event

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Increase, Ca++ (intracellular)

Downstream event

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Disruption, Mitochondrial electron transport chain

Key Event Relationship Overview

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AOPs Referencing Relationship

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AOP Name Adjacency Weight of Evidence Quantitative Understanding
Calcium-mediated neuronal ROS production and energy imbalance adjacent Moderate

Taxonomic Applicability

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Sex Applicability

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Life Stage Applicability

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Key Event Relationship Description

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Evidence Supporting this KER

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Biological Plausibility

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Empirical Evidence

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  • Mitochondrial electron transport chain disruption follows intracellular Ca++ dysregulation [1]

Uncertainties and Inconsistencies

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Quantitative Understanding of the Linkage

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Response-response Relationship

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Time-scale

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Known modulating factors

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Known Feedforward/Feedback loops influencing this KER

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Domain of Applicability

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References

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  1. Lebrecht D1, Kirschner J, Geist A, Haberstroh J, Walker UA. 2010. Cardiovasc Pathol 19(5): e167-74.