API

Event: 1134

Key Event Title

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Irreversible inhibition of hepatic VKOR by binding of AR at tyrosine 139, Failure to cycle vitamin K epoxide to vitamin K to form vitamin K hydroquinone

Short name

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Irreversible inhibition of hepatic VKOR by binding of AR at tyrosine 139, Failure to cycle

Biological Context

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Level of Biological Organization
Molecular

Cell term

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Organ term

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Key Event Components

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Process Object Action
vitamin K metabolic process vitamin K abnormal
signaling androgen receptor decreased
catalytic activity Vitamin K Epoxide Reductases decreased

Key Event Overview


AOPs Including This Key Event

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AOP Name Role of event in AOP
VKOR inhibition resulting in coagulopathy MolecularInitiatingEvent

Stressors

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Taxonomic Applicability

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Life Stages

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Sex Applicability

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Key Event Description

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How It Is Measured or Detected

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Domain of Applicability

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Evidence for Perturbation by Stressor


Overview for Molecular Initiating Event

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References

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