API

Relationship: 510

Title

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Activation, LXR leads to Inhibition, PPAR alpha

Upstream event

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Activation, LXR

Downstream event

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Inhibition, PPAR alpha

Key Event Relationship Overview

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AOPs Referencing Relationship

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AOP Name Directness Weight of Evidence Quantitative Understanding
NR1I3 (CAR) suppression leading to hepatic steatosis indirectly leads to
Molecular events lead to nonalcoholic hepatic steatosis (NASH) directly leads to

Taxonomic Applicability

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Sex Applicability

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Life Stage Applicability

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How Does This Key Event Relationship Work

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Weight of Evidence

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Biological Plausibility

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Empirical Support for Linkage

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Uncertainties or Inconsistencies

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Quantitative Understanding of the Linkage

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Evidence Supporting Taxonomic Applicability

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References

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