API

Relationship: 1189

Title

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Increased, serotonin (5-HT) 1 leads to Increased, locomotion

Upstream event

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Increased, serotonin (5-HT) 1

Downstream event

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Increased, locomotion

Key Event Relationship Overview

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AOPs Referencing Relationship

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Taxonomic Applicability

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Term Scientific Term Evidence Link
Melibe leonina Melibe leonina NCBI
Aplysia californica Aplysia californica NCBI

Sex Applicability

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Life Stage Applicability

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Key Event Relationship Description

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Evidence Supporting this KER

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Biological Plausibility

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Empirical Evidence

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Several lines of evidence exist indicating increases in serotonin or inhibition of its reuptake cause increased locomotion in mollusks. Mackey and Carew (1983)injected serotonin (5-hydroxytryptamine; 5-HT) into the bloodstream of aplysia and found it elicited locomotion (while other similar biogenic amines did not). 5-HT could still trigger locomotion after isolating the pedal and pleural ganglia from the rest of the central nervous system, suggesting that a primary site for the action of 5-HT on locomotion lies in the pedal and pleural ganglia.

Satterlie and Norekian (1996) found in the mollusc Clione limacina identified 27 paifs of serotonin-immunoreactive neurons in the central nervous system of Clione, with most of them involved in various aspects of locomotory speed modulation.

Somewhat in contrast, Lewis et al (2011) tested the effects of 5-HT in the nudibranch mollusc Melibe leonina, which both crawls and swims. No significant effect of 5-HT on the distance crawled or the speed of crawling; however, the time spent swimming was significantly increased, along with swimming speed.

Uncertainties and Inconsistencies

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Quantitative Understanding of the Linkage

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Response-response Relationship

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Time-scale

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Known modulating factors

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Known Feedforward/Feedback loops influencing this KER

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Domain of Applicability

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References

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