Upstream eventIncreased, serotonin (5-HT) 1
Increase, cilia movement
Key Event Relationship Overview
AOPs Referencing Relationship
Life Stage Applicability
Key Event Relationship Description
In bivalves, latero-frontal cirri (cilia) are positioned at the incurrent side of the gill filaments. Bands of lateral cilia within these gill filaments produce the main water transport through the interfilamentary canals of the gill (flow channels)( Riisgard and Larsen, 1995). Ciliary action is under serotinergic control so that stimulation increases water flow rate. Serotonin moves the latero-frontal cirri out of the flow path, so that there is reduced frictional pressure drop within the flow channels. Increased flow rates due to the vigorous movement of cilia within the gill filaments is also stimulated by serotonin (Gardiner et al., 1991; Carrol and Catapane, 2007).
Evidence Supporting this KER
Uncertainties and Inconsistencies
In Mytilus edulis, the beating of the cilia is induced by serotonin,but excessive stiumlation does not appear to increase pump pressure or water flow rate(Jorgensen et al, 1988). These are controled primarily by the degree of valve gaping.
Quantitative Understanding of the Linkage
Known modulating factors
Known Feedforward/Feedback loops influencing this KER
Domain of Applicability
1. Gardiner, D.B., H. Silverman, and T.H. Dietz, Musculature Associated with the Water Canals in Freshwater Mussels and Response to Monoamines In Vitro. The Biological Bulletin, 1991. 180(3): p. 453-465.
2. Riisgard, H.U. and P.S. Larsen, Filter-feeding in marine macro-invertebrates: pump characteristics, modelling and energy cost. Biological Reviews, 1995. 70(1): p. 67-106.
3. Carroll, M.A. and E.J. Catapane, The nervous system control of lateral ciliary activity of the gill of the bivalve mollusc, Crassostrea virginica. Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology, 2007. 148(2): p. 445-450.
4. Jorgensen, C.B., The bivalve pump. Mar. Ecol. Prog. Ser., 1986. 34: p. 69-77.