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Event: 1613
Key Event Title
Decrease, dihydrotestosterone (DHT) level
Short name
Biological Context
Cell term
Organ term
Key Event Components
Process | Object | Action |
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Key Event Overview
AOPs Including This Key Event
AOP Name | Role of event in AOP | Point of Contact | Author Status | OECD Status |
---|---|---|---|---|
Cyp17A1 inhibition leads to undescended testes in mammals | KeyEvent | Bérénice COLLET (send email) | Open for citation & comment | |
5α-reductase,female fish | KeyEvent | Young Jun Kim (send email) | Open for citation & comment | Under Development |
5α-reductase inhibition leading to short AGD | KeyEvent | Terje Svingen (send email) | Under development: Not open for comment. Do not cite | Under Development |
Decreased testosterone synthesis leading to short AGD | KeyEvent | Terje Svingen (send email) | Under development: Not open for comment. Do not cite | Under Development |
Stressors
Taxonomic Applicability
Life Stages
Sex Applicability
Key Event Description
Reduction in DHT synthesis leads to a reduction in DHT circulating levels. 12
How It Is Measured or Detected
DHT levels in a sample can be measured by (High Performance) Liquid Chromatography. After sample fractionation, DHT can be identify by comparison with internal standards spectrum. Quantification of DHT levels can be performed using hormones measurements kits (ELISA), instrumental techniques (LC-MS) or liquid scintillation spectrometry (after radiolabeling).3
Domain of Applicability
References
1 Miller Walter L. (1988) Molecular Biology of Steroid Hormone Synthesis. Endocrine Reviews, 9(3): 295-318.https://doi.org/10.1210/edrv-9-3-295
2 Miller W.L. and Auchus R.J. (2011) The Molecular Biology, Biochemistry, and Physiology of Human Steroidogenesis and Its Disorders. Endocrine Reviews, 32(1): 81-151.https://doi.org/10.1210/er.2010-0013
3 Shiraishi S., Lee P.W., Leung A., Goh V.H., Swerdloff R.S. and Wang C. (2008) Simultaneous measurement of serum testosterone and dihydrotestosterone by liquid chromatography-tandem mass spectrometry. Clinical chemistry, 54(11): 1855-63.https://doi.org/10.1373/clinchem.2008.103846 |