This Event is licensed under the Creative Commons BY-SA license. This license allows reusers to distribute, remix, adapt, and build upon the material in any medium or format, so long as attribution is given to the creator. The license allows for commercial use. If you remix, adapt, or build upon the material, you must license the modified material under identical terms.
Event: 2308
Key Event Title
Increased, stimulation of brain serotonin 5-HT1a, 5-HT2c receptors
Short name
Biological Context
Level of Biological Organization |
---|
Organ |
Organ term
Organ term |
---|
brain |
Key Event Components
Process | Object | Action |
---|---|---|
serotonin receptor activity | Surface of brain | increased |
Key Event Overview
AOPs Including This Key Event
AOP Name | Role of event in AOP | Point of Contact | Author Status | OECD Status |
---|---|---|---|---|
Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) leads to Inhibition, Feeding | KeyEvent | John Frisch (send email) | Under development: Not open for comment. Do not cite |
Taxonomic Applicability
Life Stages
Life stage | Evidence |
---|---|
All life stages | Moderate |
Sex Applicability
Term | Evidence |
---|---|
Unspecific | High |
Key Event Description
Serotonin (5-HT) is a neurotransmitter which stimulates pathways resulting in a variety of downstream behavior effects (McDonald 2017; Ramsteijn et al. 2020). Activation of different pathways is mediated by different receptors located in different tissue types, with serotonin receptors classified into 7 families and 14 receptor subtypes (McDonald 2017; Barnes et al. 2021). Increased levels of serotonin result in increased stimulation of serotonin 5-HT1a, 5-HT2c receptors located in brain tissue.
How It Is Measured or Detected
Stimulation of brain 5-HT1a, 5-HT2c receptors have been studied by a variety of techniques including radiolabeled compounds, receptor binding, real time PCR, in situ hybridization, Western and Northern blotting, and immunohistochemistry (Barnes et al. 2021). Stimulation of brain 5-HT1a, 5-HT2c receptors by serotonin (5-HT) is often measured indirectly by use of antagonist compounds to block activation of receptors (Ortega et al. 2013; Perez-Maceira et al. 2014; Perez-Maceria et al. 2016; Barnes et al. 2021).
Domain of Applicability
Life Stage: Applies to all life stages with developed brain and central nervous systems.
Sex: Applies to both males and females.
Taxonomic: Primarily studied in laboratory rodents, humans, and fish.
References
Barnes, N.M., Ahern, G.P., Becamel, C., Bockaert, J., Camilleri, M., Chaumont-Dubel, S., Claeysen, S., Cunningham, K.A., Fone, K.C., Gershon, M., Di Giovanni, G., Goodfellow, N.M., Halberstadt, A.L., Hartley, R.M., Hassaine, G., Herrick-Davis, K., Hovius, R., Lacivita, E., Lambe, E..K, Leopoldo, M., Levy, F.O., Lummis, S.C.R, Marin, P., Maroteaux, L., McCreary, A.C., Nelson, D.L., Neumaier, J.F., Newman-Tancredi, A., Nury, H., Roberts, A., Roth, B.L., Roumier, A., Sanger, G.J., Teitler, M., Sharp, T., Villalon, C.M., Vogel, H., Watts, S.W., and Hoyer, D. 2021. International Union of Basic and Clinical Pharmacology. CX. Classification of Receptors for 5-hydroxytryptamine; Pharmacology and Function. Pharmacological Reviews 73(1): 310-520.
McDonald, M.D. 2017. An AOP analysis of selective serotonin reuptake inhibitors (SSRIs) for fish. Comparative Biochemistry and Physiology, Part C-Toxicology and Pharmacology 197: 19–31.
Ortega, V.A., Lovejoy, D.A., and Bernier, N.J. 2013. Appetite-suppressing effects and interactions of centrally administered corticotropin-releasing factor, urotensin I and serotonin in rainbow trout (Oncorhynchus mykiss). Frontiers in Neuroscience 7: 196.
Perez-Maceira, J.J., Mancebo, M.J., and Aldegunde, M. 2014. The involvement of 5-HT-like receptors in the regulation of food intake in rainbow trout (Oncorhynchus mykiss). Comparative Biochemistry and Physiology, Part C-Toxicology and Pharmacology 161: 1–6.
Perez-Maceira, J.J., Otero-Rodino, C., Mancebo, M.J., Soengas, J.L., and Aldegunde, M. 2016. Food intake inhibition in rainbow trout induced by activation of serotonin 5‑HT2C receptors is associated with increases in POMC, CART and CRF mRNA abundance in hypothalamus. Comparative Biochemistry and Physiology, Part B-Biochemical Systems and Environmental Physiology 186(3): 313-321.
Ramsteijn A.S., Van de Wijer, L., Rando, J., van Luijk, J., Homberg, J.R., and Olivier, J.D.A. 2020. Perinatal selective serotonin reuptake inhibitor exposure and behavioral outcomes: A systematic review and meta-analyses of animal studies. Neuroscience and Biobehavior Reviews 114: 53–69.
NOTE: Italics symbolize edits from John Frisch January 2025.