API

Event: 807

Key Event Title

?

Decreased, cholesterol

Short name

?

Decreased, cholesterol

Biological Context

?

Level of Biological Organization
Cellular

Cell term

?


Organ term

?

Organ term
liver


Key Event Components

?

Process Object Action
cholesterol biosynthetic process cholesterol decreased

Key Event Overview


AOPs Including This Key Event

?

AOP Name Role of event in AOP
HMGCR inhibition to male fertility KeyEvent

Stressors

?


Taxonomic Applicability

?

Term Scientific Term Evidence Link
Vertebrates Vertebrates High NCBI

Life Stages

?


Sex Applicability

?

Term Evidence
Male High
Female High

Key Event Description

?


Most cholesterol synthesis occurs within the endoplasmic reticulum of hepatic cells. First, acetyl-CoA is converted to HMG-CoA via HMG-CoA synthase. Next, HMG-CoA is converted to mevalonate via HMG-CoA reductase. Several other steps follow, but this is the rate-limiting step of cholesterol synthesis. Statin drugs inhibit HMG-CoA reductase to reduce cholesterol. Cholesterol synthesis may also occur to a limited extent in steroidogenic cells where it’s used to produce steroid hormones (Azhar et al. 2007)


How It Is Measured or Detected

?


Commerical assay kits are available for measuring cholesterol


Domain of Applicability

?


Cholesterol is not synthesized in plants (Behrman and Gopalan 2005)


Evidence for Perturbation by Stressor



Gemfibrozil

Juvenile female rainbow trout have decreased cholesterol (including total, HDL, LDL, & VLDL) after exposure to gemfibrozil (Prindiville et al. 2011)

Male and female zebrafish fed gemfibrozil alone or in combination with atorvastatin have decreased cholesterol (Al-Habsi et al. 2016)


Bezafibrate

Adult male zebrafish fed bezafibrate have decreased cholesterol (Velasco-Santamaría et al. 2011)


Clofibrate

Feeding grass carp either a high-fat or high-carbohydrate diet causes increases in total cholesterol, HDL, and LDL. Clofibrate reduces the high cholesterol levels caused by these diets to levels similar to controls (Guo et al. 2015)


Fenofibrate

Feeding fenofibrate to grass carp on a high fat diet causes a decrease in cholesterol, LDL, body weight, and whole-body lipid content (Du et al. 2008)


Atorvastatin

Male and female zebrafish fed atorvastatin alone or in combination with gemfibrozil have decreased whole-bodycholesterol (Al-Habsi et al. 2016)


References

?