API

Relationship: 1276

Title

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Excitation, Trigeminal nerve excitation leads to Increased Airway Hyper-responsiveness,Cough, Dyspnea

Upstream event

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Excitation, Trigeminal nerve excitation

Downstream event

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Increased Airway Hyper-responsiveness,Cough, Dyspnea

Key Event Relationship Overview

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AOPs Referencing Relationship

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Taxonomic Applicability

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Sex Applicability

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Life Stage Applicability

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Key Event Relationship Description

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Action potential propagation in afferent trigeminal and vagal nerves is widely known to mediate coughing, dyspnea, and other bodily reactions to irritation.

Evidence Supporting this KER

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Biological Plausibility

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Empirical Evidence

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See Alarie (1973)for review of basic observations of the trigeminal nerves in irritation.

Uncertainties and Inconsistencies

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Quantitative Understanding of the Linkage

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Response-response Relationship

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Time-scale

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Known modulating factors

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Known Feedforward/Feedback loops influencing this KER

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Domain of Applicability

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References

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