API

Event: 1223

Key Event Title

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Trigeminal and/or vagal nerve excitation causes Airway Hyper-responsiveness,Cough, Dyspnea

Short name

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Increased Airway Hyper-responsiveness,Cough, Dyspnea

Biological Context

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Level of Biological Organization
Tissue


Organ term

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Organ term
respiratory tract


Key Event Components

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Process Object Action
reflex trigeminal nerve increased
cough increased
Respiratory Hypersensitivity increased
Dyspnea increased

Key Event Overview


AOPs Including This Key Event

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AOP Name Role of event in AOP
TRPA1 activation leads to pulmonary sensory irritation AdverseOutcome

Stressors

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Taxonomic Applicability

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Life Stages

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Sex Applicability

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Key Event Description

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How It Is Measured or Detected

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Domain of Applicability

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Regulatory Significance of the Adverse Outcome

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References

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