API

Relationship: 1898

Title

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Increase, DNA Damage leads to Tissue resident cell activation

Upstream event

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Increase, DNA Damage

Downstream event

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Tissue resident cell activation

Key Event Relationship Overview

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AOPs Referencing Relationship

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AOP Name Adjacency Weight of Evidence Quantitative Understanding
Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer adjacent Moderate Not Specified
Increased DNA damage leading to increased risk of breast cancer adjacent Moderate Not Specified

Taxonomic Applicability

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Sex Applicability

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Life Stage Applicability

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Key Event Relationship Description

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Evidence Supporting this KER

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Biological Plausibility

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High. Biological plausibility is high since DNA damage generates inflammatory signals (DAMPS).

Empirical Evidence

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Uncertainties and Inconsistencies

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Quantitative Understanding of the Linkage

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Response-response Relationship

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Time-scale

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Known modulating factors

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Known Feedforward/Feedback loops influencing this KER

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Domain of Applicability

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References

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