API

Relationship: 1676

Title

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Increase, Cytotoxicity (renal tubular cell) leads to Occurrence, Kidney toxicity

Upstream event

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Increase, Cytotoxicity (renal tubular cell)

Downstream event

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Occurrence, Kidney toxicity

Key Event Relationship Overview

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AOPs Referencing Relationship

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AOP Name Adjacency Weight of Evidence Quantitative Understanding
Inhibition of mitochondrial DNA polymerase gamma leading to kidney toxicity adjacent High Moderate
Receptor mediated endocytosis and lysosomal overload leading to kidney toxicity adjacent High Moderate
Renal protein alkylation leading to kidney toxicity adjacent High Moderate

Taxonomic Applicability

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Sex Applicability

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Life Stage Applicability

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Key Event Relationship Description

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Evidence Supporting this KER

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Biological Plausibility

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Empirical Evidence

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Uncertainties and Inconsistencies

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Quantitative Understanding of the Linkage

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Response-response Relationship

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Time-scale

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Known modulating factors

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Known Feedforward/Feedback loops influencing this KER

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Domain of Applicability

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References

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