Upstream eventIncreased, Mortality
Decreased, Population trajectory
Key Event Relationship Overview
AOPs Referencing Relationship
|AOP Name||Adjacency||Weight of Evidence||Quantitative Understanding|
|Acetylcholinesterase inhibition leading to acute mortality||adjacent||Moderate||Moderate|
|AhR activation leading to early life stage mortality||adjacent||Moderate||Low|
Life Stage Applicability
|All life stages||High|
Key Event Relationship Description
Evidence Supporting this KER
- Survival to reproductive maturity is a parameter of demographic significance. Assuming resource availability (i.e., food, habitat, etc.) is not limiting to the extant population, sufficient mortality in the reproductive population may ultimately lead to declining population trajectories.
Uncertainties and Inconsistencies
There are scenarios in which individual mortality may not lead to declining population size. These include instances were populations are limited by available habitat and food resource and can be replenished through immigration.
Quantitative Understanding of the Linkage
Assuming other relevant demographic parameters are available, the effect of increased mortality rates on population status can be quantitatively predicted using standard population modeling approaches.
Known modulating factors
Known Feedforward/Feedback loops influencing this KER
Domain of Applicability
All organisms must survive to reproductive age in order to reproduce and sustain populations.