Upstream eventIncreased, Mortality
Decreased, Population trajectory
Key Event Relationship Overview
AOPs Referencing Relationship
|AOP Name||Directness||Weight of Evidence||Quantitative Understanding|
|Acetylcholinesterase inhibition leading to acute mortality||directly leads to||Moderate||Moderate|
|AhR activation leading to early life stage mortality||directly leads to||Moderate||Weak|
Life Stage Applicability
How Does This Key Event Relationship Work
Weight of Evidence
- Survival to reproductive maturity is a parameter of demographic significance. Assuming resource availability (i.e., food, habitat, etc.) is not limiting to the extant population, sufficient mortality in the reproductive population may ultimately lead to declining population trajectories.
Empirical Support for Linkage
Uncertainties or Inconsistencies
There are scenarios in which individual mortality may not lead to declining population size. These include instances were populations are limited by available habitat and food resource and can be replenished through immigration.
Quantitative Understanding of the Linkage
Assuming other relevant demographic parameters are available, the effect of increased mortality rates on population status can be quantitatively predicted using standard population modeling approaches.
Evidence Supporting Taxonomic Applicability
All organisms must survive to reproductive age in order to reproduce and sustain populations.