API

Relationship: 428

Title

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Increased, Mortality leads to Decreased, Population trajectory

Upstream event

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Increased, Mortality

Downstream event

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Decreased, Population trajectory

Key Event Relationship Overview

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AOPs Referencing Relationship

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AOP Name Adjacency Weight of Evidence Quantitative Understanding
Acetylcholinesterase inhibition leading to acute mortality adjacent Moderate Moderate
AhR activation leading to early life stage mortality adjacent Moderate Low

Taxonomic Applicability

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Sex Applicability

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Sex Evidence
Unspecific High

Life Stage Applicability

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Term Evidence
All life stages High

Key Event Relationship Description

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Evidence Supporting this KER

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Biological Plausibility

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  • Survival to reproductive maturity is a parameter of demographic significance. Assuming resource availability (i.e., food, habitat, etc.) is not limiting to the extant population, sufficient mortality in the reproductive population may ultimately lead to declining population trajectories.

Empirical Evidence

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n/a

Uncertainties and Inconsistencies

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There are scenarios in which individual mortality may not lead to declining population size. These include instances were populations are limited by available habitat and food resource and can be replenished through immigration.

Quantitative Understanding of the Linkage

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Assuming other relevant demographic parameters are available, the effect of increased mortality rates on population status can be quantitatively predicted using standard population modeling approaches.

Response-response Relationship

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Time-scale

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Known modulating factors

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Known Feedforward/Feedback loops influencing this KER

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Domain of Applicability

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All organisms must survive to reproductive age in order to reproduce and sustain populations.

References

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