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Relationship: 2360
Title
Coagulation leads to Diminished Protective Response to ROS
Upstream event
Downstream event
Key Event Relationship Overview
AOPs Referencing Relationship
AOP Name | Adjacency | Weight of Evidence | Quantitative Understanding | Point of Contact | Author Status | OECD Status |
---|---|---|---|---|---|---|
Binding to ACE2 leading to thrombosis and disseminated intravascular coagulation | adjacent | Moderate | Not Specified | Shihori Tanabe (send email) | Under development: Not open for comment. Do not cite | Under Development |
Taxonomic Applicability
Term | Scientific Term | Evidence | Link |
---|---|---|---|
human | Homo sapiens | Moderate | NCBI |
Sex Applicability
Sex | Evidence |
---|---|
Unspecific | Moderate |
Life Stage Applicability
Term | Evidence |
---|---|
All life stages | Moderate |
Key Event Relationship Description
Blood coagulation through activation and recruitment of platelets following vessel-wall injury induces formation of thrombin through coagulation cascade, which induces reactive oxygen species generation by NOX enzymes in vascular cells (André-Lévigne D et al., 2017).
Evidence Collection Strategy
The references were searched with terms "ROS" and "coagulation" in NCBI database. The references that have relevant insights where coagulation leads to diminished protective response to ROS were selected and cited.
Evidence Supporting this KER
Biological Plausibility
Empirical Evidence
Uncertainties and Inconsistencies
Known modulating factors
Modulating Factor (MF) | MF Specification | Effect(s) on the KER | Reference(s) |
---|---|---|---|
Quantitative Understanding of the Linkage
Response-response Relationship
Time-scale
Known Feedforward/Feedback loops influencing this KER
Domain of Applicability
References
André-Lévigne D, Modarressi A, Pepper MS, Cuenod BP. (2017) Reactive Oxygen Species and NOX Enzymes Are Emerging as Key Players in Cutaneous Wound Repair. Int J Mol Sci. 18(10):2149.