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Coagulation leads to Diminished Protective Response to ROS
Key Event Relationship Overview
AOPs Referencing Relationship
|AOP Name||Adjacency||Weight of Evidence||Quantitative Understanding||Point of Contact||Author Status||OECD Status|
|Binding to ACE2 leading to thrombosis and disseminated intravascular coagulation||adjacent||Moderate||Not Specified||Shihori Tanabe (send email)||Under development: Not open for comment. Do not cite||Under Development|
Life Stage Applicability
|All life stages||Moderate|
Key Event Relationship Description
Blood coagulation through activation and recruitment of platelets following vessel-wall injury induces formation of thrombin through coagulation cascade, which induces reactive oxygen species generation by NOX enzymes in vascular cells (André-Lévigne D et al., 2017).
Evidence Collection Strategy
The references were searched with terms "ROS" and "coagulation" in NCBI database. The references that have relevant insights where coagulation leads to diminished protective response to ROS were selected and cited.
Evidence Supporting this KER
Uncertainties and Inconsistencies
Known modulating factors
|Modulating Factor (MF)||MF Specification||Effect(s) on the KER||Reference(s)|
Known Feedforward/Feedback loops influencing this KER
Domain of Applicability
André-Lévigne D, Modarressi A, Pepper MS, Cuenod BP. (2017) Reactive Oxygen Species and NOX Enzymes Are Emerging as Key Players in Cutaneous Wound Repair. Int J Mol Sci. 18(10):2149.