API

Event: 1605

Key Event Title

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Accumulation of misfolded proteins

Short name

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Accumulation, misfolded proteins

Biological Context

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Level of Biological Organization
Cellular

Cell term

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Organ term

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Key Event Components

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Process Object Action

Key Event Overview


AOPs Including This Key Event

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AOP Name Role of event in AOP
Inhibition of N-linked glycosylation leads to liver injury KeyEvent

Stressors

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Taxonomic Applicability

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Life Stages

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Sex Applicability

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Key Event Description

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Accumulation of misfolded proteins in the Endoplasmic Reticulum


How It Is Measured or Detected

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Fibril formation, morphology and secondary structure content of proteins can be monitored in vitro by molecular probes, TEM/AFM, and CD/FTIR analyses, respectively.(Gregoire, et al 2013)


Domain of Applicability

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References

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Gregoire, Simpson; Irwin, Jacob; Kwon, I. (2013). Technique for monitoring protein misfolding and aggregation in vitro and in living cells. Korean J Chem Eng, 29(6), 693–702. https://doi.org/10.1007/s11814-012-0060-x.Techniques