API

Relationship: 635

Title

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Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) leads to Increased, serotonin (5-HT) 1

Upstream event

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Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT)

Downstream event

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Increased, serotonin (5-HT) 1

Key Event Relationship Overview

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AOPs Referencing Relationship

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Taxonomic Applicability

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Sex Applicability

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Life Stage Applicability

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Key Event Relationship Description

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Inhibition of the reuptake of serotonin results in increased residence time and activity of serotonin in synapses.

Evidence Supporting this KER

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Biological Plausibility

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Empirical Evidence

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Uncertainties and Inconsistencies

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Quantitative Understanding of the Linkage

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Response-response Relationship

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Time-scale

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Known modulating factors

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Known Feedforward/Feedback loops influencing this KER

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Domain of Applicability

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References

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