API

Event: 116

Key Event Title

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Activation, FAS

Short name

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Activation, FAS

Key Event Component

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Process Object Action
fatty acid synthase activity fatty acid synthase increased

Key Event Overview


AOPs Including This Key Event

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AOP Name Role of event in AOP
LXR activation leading to hepatic steatosis KeyEvent

Stressors

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Level of Biological Organization

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Biological Organization
Molecular

Cell term

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Cell term
hepatocyte


Organ term

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Taxonomic Applicability

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Life Stages

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Sex Applicability

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How This Key Event Works

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LXR agonist treatment has been shown to induce the genes encoding fatty acid synthase (FAS) in SREBP-1c-deficient mice [1], [2], [3].

This finding shows that in parallel with the increase of FAS expression from the SREBP-1c [2], [3], [4] and the ChREBP the enzyme is also directly induced from the LXR.


How It Is Measured or Detected

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Evidence Supporting Taxonomic Applicability

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References

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  1. Oisterveer et al. 2010
  2. 2.0 2.1 Liang et al. 2002
  3. 3.0 3.1 Schultz et al. 2000
  4. Horton et al. 2002