API

Event: 951

Key Event Title

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KE8 : Increase, Vascular Resistance

Short name

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Increase, Vascular Resistance

Biological Context

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Level of Biological Organization
Organ


Organ term

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Organ term
circulatory system


Key Event Components

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Process Object Action
increased systemic vascular resistance increased

Key Event Overview


AOPs Including This Key Event

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AOP Name Role of event in AOP
Hypertension KeyEvent

Stressors

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Taxonomic Applicability

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Term Scientific Term Evidence Link
Homo sapiens Homo sapiens High NCBI
Rattus norvegicus Rattus norvegicus Low NCBI

Life Stages

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Life stage Evidence
All life stages High

Sex Applicability

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Term Evidence
Unspecific High

Key Event Description

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Vascular resistance is the resistance to blood flow in the circulatory system (Siddiqui, 2011). Systemic vascular resistance (SVR), also known as total peripheral resistance, refers specifically to the resistance to blood flow offered by the peripheral circulation. Vasodilation decreases SVR while vasoconstriction or impaired vasodilation increases SVR.


How It Is Measured or Detected

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Vascular resistance cannot be measured by any direct means, but can be calculated using a formula: (mean arterial pressure minus mean right arterial pressure) divided by cardiac output (Siddiqui 2011).


Domain of Applicability

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Increased SVR was observed in humans, pigs and rats (Siddiqui 2011, Dikalova et al. 2016, 

 


References

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Siddiqui, A. (2011). Effects of Vasodilation and Arterial Resistance on Cardiac Output. J. Clin. Exp. Cardiol. 02.

Dikalova A, Aschner JL, Kaplowitz MR, Summar M, Fike CD.  Tetrahydrobiopterin oral therapy recouples eNOS and ameliorates chronic hypoxia-induced pulmonary hypertension in newborn pigs.  Am J Physiol Lung Cell Mol Physiol. 2016, 1;311(4):L743-L753.