API

Event: 724

Key Event Title

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Inhibition, Pyruvate dehydrogenase kinase (PDK) enzyme

Short name

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Inhibition, Pyruvate dehydrogenase kinase (PDK) enzyme

Biological Context

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Level of Biological Organization
Cellular

Cell term

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Organ term

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Key Event Components

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Process Object Action
pyruvate dehydrogenase activity Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial (rat) decreased

Key Event Overview


AOPs Including This Key Event

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AOP Name Role of event in AOP
PDK inhibition- HCC MolecularInitiatingEvent

Stressors

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Taxonomic Applicability

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Life Stages

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Sex Applicability

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Key Event Description

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How It Is Measured or Detected

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Domain of Applicability

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Evidence for Perturbation by Stressor


Overview for Molecular Initiating Event

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References

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