API

Relationship: 1825

Title

?

Impaired IL-1 signaling leads to Suppressed MyD88

Upstream event

?

Impaired IL-1 signaling

Downstream event

?


Suppressed MyD88

Key Event Relationship Overview

?


AOPs Referencing Relationship

?

AOP Name Adjacency Weight of Evidence Quantitative Understanding
Inhibition of IL-1 signaling adjacent High High

Taxonomic Applicability

?

Sex Applicability

?

Life Stage Applicability

?

Key Event Relationship Description

?


Evidence Supporting this KER

?


Biological Plausibility

?

The trimeric complex consists of IL-1, IL-1R1 and IL-1R3 (a coreceptor, formerly IL-1R accessory protein) allows for the approximation of the Toll-IL-1-Receptor (TIR) domains of each receptor chain. MyD88 then binds to the TIR domains. The binding of MyD88 triggers a cascade of kinases  to activation of NF-κB. (Dinaarello et al.)

Empirical Evidence

?

Uncertainties and Inconsistencies

?

Quantitative Understanding of the Linkage

?


There is no report to quantitatively measue MyD88 activation.

Response-response Relationship

?

There is no report to quantitatively measue MyD88 activation.

Time-scale

?

Known modulating factors

?

Known Feedforward/Feedback loops influencing this KER

?

Domain of Applicability

?


References

?